Synthesis of L-beta-3'-deoxy-3',3'-difluoro-4'-thionucleosides
Feng Zheng1, Xiao-Hua Zhang, Xiao-Long Qiu
1Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Organic Letters
|December 15, 2006
Abstract:
[Structure: see text] An efficient route to L-beta-3'-deoxy-3',3'-difluoro-4'-thionucleosides, thio-containing analogues of highly bioactive gemcitabine, is described. Our synthesis highlighted the installation of the thioacetyl group in high efficiency and construction of 3-deoxy-3,3-difluorothiofuranose skeleton in a novel method.
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