Related Experiment Video
Updated: Jul 18, 2026

11:40
Quantitative Autonomic Testing
Published on: July 19, 2011
Iontophoresis for palmoplantar hyperhidrosis.
1praxis@kreyden.ch
Journal of Cosmetic Dermatology
|December 15, 2006
Summary
Tap water iontophoresis (TWI) is a safe, effective, and affordable home treatment for palmoplantar hyperhidrosis (HH). This review details TWI
Area of Science:
- Dermatology
- Medical Technology
Background:
- Palmoplantar hyperhidrosis (HH) pathogenesis is unknown, preventing causative therapies.
- Current HH treatments include topical agents, iontophoresis, botulinum toxin, and surgery.
Purpose of the Study:
- To review the literature on tap water iontophoresis (TWI) for palmoplantar HH.
- To discuss TWI's historical development, mechanism, indications, and administration.
Main Methods:
- Literature review of TWI for palmoplantar hyperhidrosis.
Main Results:
- TWI is a non-invasive, safe, well-tolerated, efficient, and inexpensive treatment.
- Patients can self-administer TWI at home.
- TWI is considered the optimal treatment for palmoplantar HH resistant to aluminum salts.
Conclusions:
- TWI is a valuable therapeutic option for palmoplantar hyperhidrosis.
- Understanding TWI's mechanism, involving anodal current and potential acrosyringium effects, is ongoing.
- TWI offers a practical and effective solution for managing this condition.
Related Concept Videos
Hand hygiene
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
Decreased Body Temperature
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Thermosensation
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

