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Prevention of murine cerebral malaria by a stable prostacyclin analog
K Sliwa1, H J Grundmann, S Neifer
1Landesinstitut für Tropenmedizin Berlin, Germany.
Infection and Immunity
|October 1, 1991
Abstract:
Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.