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AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists

R R Hantgan1, M C Stahle, J H Connor

  • 1Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1019, USA. hantgan@wfubmc.edu

Journal of Thrombosis and Haemostasis : JTH
|December 15, 2006
PubMed
Summary

Glycoprotein IIb/IIIa inhibitors, while blocking platelet interactions, can paradoxically increase thrombosis risk by leaving the alpha(IIb)beta(3) receptor in an activated state. Understanding these mechanisms is key to improving safety and efficacy.

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