Related Experiment Video
Updated: Jul 18, 2026
08:59
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Peripheral nervous system involvement in patients with cancer
Jean-Christophe Antoine1, Jean-Philippe Camdessanché
1Service de Neurologie, Hôpital Bellevue, CHU de Saint-Etienne. j.christophe.antoine@chu-st-etienne.fr
The Lancet. Neurology
|December 15, 2006
Summary
Cancer frequently affects the peripheral nervous system (PNS), leading to various disorders. This review details the causes, mechanisms, assessment, and diagnosis of these cancer-related PNS conditions.
Area of Science:
- Neurology
- Oncology
- Neuro-oncology
Background:
- Peripheral nervous system (PNS) involvement is a frequent complication in cancer patients.
- Cancer-related PNS disorders can affect various components, including motor neurons, sensory ganglia, and peripheral nerves.
Purpose of the Study:
- To review the diverse causes and mechanisms of PNS disorders in cancer patients.
- To focus on the assessment and diagnostic strategies for these conditions.
Main Methods:
- Comprehensive literature review of cancer-related PNS disorders.
- Analysis of etiological factors and pathomechanisms.
- Discussion of diagnostic approaches.
Main Results:
- PNS damage can result from tumor infiltration, treatment toxicity, metabolic issues, cachexia, infections, and paraneoplastic syndromes.
- The specific type of cancer (lymphoma or solid tumor) influences the nature of the PNS disorder.
- Various diagnostic tools are employed for accurate identification.
Conclusions:
- Understanding the multifaceted causes of PNS disorders in cancer is crucial for effective management.
- Accurate diagnosis relies on a thorough evaluation of potential mechanisms and appropriate diagnostic methods.
- Further research into early detection and targeted therapies is warranted.
Related Concept Videos
01:24Peripheral Nervous System: Ganglia and Nerves
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
01:19Psychoneuroimmunology: Diabetes and Cancer
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...