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Updated: Jul 18, 2026
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient (ADC) determination in normal and
K Chaumoitre1, N Colavolpe1, R Shojai2
1Department of Medical Imaging, Hôpital Nord, CHU Marseille, France.
Summary
Diffusion-weighted MRI (DW-MRI) can evaluate fetal kidneys. Apparent diffusion coefficient (ADC) values and maps show promise for diagnosing fetal kidney conditions like nephropathy and twin-twin transfusion syndrome (TTTS).
Area of Science:
- Fetal medicine
- Diagnostic imaging
- Magnetic Resonance Imaging (MRI)
Background:
- Diffusion-weighted magnetic resonance imaging (DW-MRI) is an advanced MRI technique.
- Assessing fetal kidney development and pathology requires accurate imaging methods.
- Apparent diffusion coefficient (ADC) quantifies water molecule diffusion, reflecting tissue microstructural integrity.
Observation:
- DW-MRI was performed on fetuses between 23-38 gestational weeks.
- Studies included normal fetal kidneys and those with various pathologies: nephropathy, renal tract dilatation, renal venous thrombosis, and twin-twin transfusion syndrome (TTTS).
- ADC values were measured in the renal parenchyma.
Findings:
- Normal fetal kidney ADC values ranged from 1.1 to 1.8 x 10(-3) mm2/s, with no significant age-dependent changes.
- While ADC values were not always abnormal in nephropathy, ADC maps revealed pathological findings.
- In TTTS, donor twins exhibited higher ADC than recipient twins, correlating with syndrome severity.
Implications:
- Fetal kidney ADC measurement and ADC maps are feasible and valuable diagnostic tools.
- DW-MRI aids in evaluating fetal kidney conditions, including nephropathy, dilatation, and vascular pathologies like TTTS.
- This technique complements existing methods for comprehensive fetal renal assessment.
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