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A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
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Activation of neural stem and progenitor cells after brain injury

Darry K Miles1, Steven G Kernie

  • 1Department of Pediatrics and Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Progress in Brain Research
|December 16, 2006
PubMed

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...