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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Randomized trials and collaborative research in epilepsy surgery: future directions.

Samuel Wiebe1, Nathalie Jette

  • 1Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|December 16, 2006
PubMed
Summary

Randomized controlled trials (RCTs) in epilepsy surgery are rare and challenging. Canada can establish a national initiative for high-quality, sustainable epilepsy surgery research.

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Stereo-Electro-Encephalo-Graphy (SEEG) With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
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Stereo-Electro-Encephalo-Graphy (SEEG) With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

Area of Science:

  • Neurosurgery
  • Epileptology
  • Clinical Trials

Background:

  • Randomized controlled trials (RCTs) are the gold standard for evaluating interventions but are challenging in epilepsy surgery.
  • Limited RCT activity exists in epilepsy surgery research globally.

Purpose of the Study:

  • To assess the current level of RCT activity in epilepsy surgery worldwide.
  • To propose feasible alternatives and sustainable research initiatives for epilepsy surgery.

Main Methods:

  • Systematic review of global literature on RCTs in epilepsy surgery.
  • Analysis of personal experience with RCTs and successful Canadian research networks.

Main Results:

  • Identified 12 RCTs involving 692 patients, focusing on vagus nerve stimulation, electrostimulation, surgical techniques, and medical vs. surgical therapy.
  • Most studies were short-term (median 3 months); only temporal lobe epilepsy had RCT comparisons for resective surgery.
  • No multicenter Canadian surgical RCTs were identified.

Conclusions:

  • The adoption of RCTs in epilepsy surgery has been slow and difficult globally.
  • Canada's healthcare system and established epilepsy centers position it to lead a national research initiative.
  • Developing a national epilepsy surgery research initiative can foster high-quality, sustainable research.