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[Relationship between corrected QT interval and cardiovascular risk factors in young healthy adults: the Kangwha

Song Vogue Ahn1, Hyeon Chang Kim, Nam Wook Hur

  • 1Department of Preventive Medicine, Yonsei University College of Medicine.

Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi
|December 16, 2006
PubMed

Insights

In young adults, the heart rate-corrected QT (QTc) interval is linked to cardiovascular risk. This study found QTc interval is associated with waist-hip ratio in men and systolic blood pressure in women.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Public Health

Background:

  • Prolonged heart rate-corrected QT (QTc) interval is linked to cardiovascular risks.
  • Limited research exists on QTc interval and cardiovascular risk factors in young, healthy populations.
  • Understanding these associations in youth is crucial for early cardiovascular disease prevention.

Purpose of the Study:

  • To investigate the relationship between the QTc interval and cardiovascular risk factors in young, healthy adults.
  • To identify specific risk factors associated with QTc interval prolongation in this demographic.
  • To provide insights for early cardiovascular risk assessment in young individuals.

Main Methods:

  • Utilized data from the Kangwha study, a long-term follow-up of cardiovascular risk factors.
  • Measured QTc interval using electrocardiograms in 127 men and 149 women aged 25 years.
  • Assessed cardiovascular risk factors including anthropometrics, blood pressure, blood chemistry, and health behaviors.

Main Results:

  • Women exhibited a significantly longer mean QTc interval (419±17ms) compared to men (405±17ms).
  • A positive correlation was observed between QTc interval and waist-hip ratio in men (p=0.030).
  • In women, the QTc interval positively correlated with systolic blood pressure (p=0.017).
  • Multiple regression analysis confirmed independent associations: QTc with waist-hip ratio in men (p=0.012) and QTc with systolic blood pressure in women (p=0.020).

Conclusions:

  • The QTc interval is independently associated with the waist-hip ratio in young, healthy Korean men.
  • The QTc interval is independently associated with systolic blood pressure in young, healthy Korean women.
  • These findings highlight sex-specific cardiovascular risk factor associations with QTc interval in young adults.
Abstract

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