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Updated: Jul 18, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Does povidone-iodine liposome hydrogel influence postoperative intra-abdominal adhesions?
M A Adibelli1, A H Ozcan, K Kismet
1Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
Purpose:
To evaluate the effect of PVP-I liposome hydrogel on intraperitoneal postoperative adhesions.
Material And Methods:
Thirty Wistar -Albino male rats were randomly divided into three groups. After midline laparotomy, a 1 cm(2) area of the caecum was abraded with a sterile gauze until subserosal haemorrhage had developed. A 1 x 1 cm patch of peritoneum located opposite of caecal abrasion was completely dissected. In group 1 (control group, C) adhesion induction was performed and nothing was applied to the wounds. In group 2 and 3, PVP-I solution (3%) (group 2, PI) and PVP-I liposome hydrogel (group 3, PIL) were applied to the caecal abrasion areas and peritoneal defects. Adhesions were classified according to a classification system based on the evaluation of the appearance, extent and strength of the adhesions on postoperative 2lst day.
Results:
There was no significant difference of the adhesion scores between the groups (U1 = 45, p > 0.05 ; U2 = 48, p > 0.05 ; U3 = 47.5, p > 0.05).
Conclusions:
We found that PVP liposome hydrogel did not influence postoperative intraabdominal adhesions and should be further explored for its potential use in various intraabdominal procedures.
