Related Experiment Videos
Histamine release during paediatric cardiopulmonary bypass
D E Withington1, M Elliot, W K Man
1Department of Anaesthesia, Hospital for Sick Children, London, UK.
Agents and Actions
|May 1, 1991
Summary
Histamine is released during pediatric cardiopulmonary bypass, particularly after reperfusion. Higher left atrial histamine levels suggest release from the pulmonary vasculature.
Area of Science:
- Cardiovascular Surgery
- Pharmacology
- Physiology
Background:
- Pediatric cardiopulmonary bypass involves complex physiological changes.
- Histamine is a mediator involved in inflammatory and vascular responses.
Purpose of the Study:
- To investigate histamine release during pediatric cardiopulmonary bypass.
- To determine the source of histamine release post-reperfusion.
Main Methods:
- Measurement of histamine levels in atrial blood during pediatric cardiopulmonary bypass.
- Comparison of histamine levels between left and right atria.
Main Results:
- Histamine release was observed upon aortic cross-clamp removal.
- Left atrial histamine levels were significantly higher than right atrial levels post-reventilation (p < 0.02).
Conclusions:
- Histamine is released during pediatric cardiopulmonary bypass.
- Pulmonary vasculature is a likely source of histamine release following reperfusion.