Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Desensitization at the interface.

James R Howe1

  • 1Department of Pharmacology, Yale University School of Medicine, SHM B-251, 333 Cedar Street, New Haven, Connecticut 06520, USA. james.howe@yale.edu

ACS Chemical Biology
|December 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiomic analyses delineate human neuroendocrine tumor cell states in relation to normal enteroendocrine cell ontogeny.

The Journal of clinical investigation·2026
Same author

Control of innate olfactory valence by segregated cortical amygdala circuits.

eLife·2026
Same author

Surgical management of pancreatic neuroendocrine tumours.

The British journal of surgery·2026
Same author

Impact of biliary fungal contamination on outcomes after pancreaticoduodenectomy for pancreatic cancer.

Frontiers in oncology·2026
Same author

Surgical management of small intestinal neuroendocrine tumours.

The British journal of surgery·2026
Same author

Variable GLP-1 receptor expression across diverse neuroendocrine neoplasms: implications for incretin therapies.

Endocrine oncology (Bristol, England)·2025

Ligand-gated ion channels enable rapid brain signaling but can desensitize. Recent structural data reveal molecular mechanisms behind their activation and desensitization, crucial for normal brain function.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biophysics

Background:

  • Normal brain function relies on rapid millisecond-timescale signaling.
  • Ligand-gated ion channels, particularly those activated by glutamate, mediate fast excitatory neurotransmission.
  • These channels exhibit rapid desensitization during sustained high-frequency neuronal firing.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing the activation of ligand-gated ion channels.
  • To understand the structural basis of rapid channel desensitization.
  • To provide insights into how these processes impact normal brain function.

Main Methods:

  • Analysis of recent structural data of ligand-gated ion channels.
  • Computational modeling of channel gating and desensitization.

Related Experiment Videos

  • Biophysical characterization of channel function.

    • Main Results:

    • Structural insights into the conformational changes during channel activation.
    • Identification of key molecular determinants underlying channel desensitization.
    • Correlation between structural features and functional properties of the channels.

    Conclusions:

    • Understanding channel activation and desensitization at a molecular level is critical for comprehending neural signaling.
    • Structural data provide a foundation for future research into modulating channel function.
    • These findings contribute to our knowledge of the molecular basis of brain function and dysfunction.