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Updated: Jul 18, 2026

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
09:44

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Published on: March 3, 2015

Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets

Bhagavathi A Narayanan1

  • 1New York University School of Medicine, Department of Environmental Medicine, Tuxedo, NY 10987, USA. bhagavathi@env.med.nyu.edu

Current Cancer Drug Targets
|December 16, 2006
PubMed

Insights

Chemoprevention agents like antioxidants and phytochemicals can control various cancers by altering gene expression. DNA microarrays help identify these gene targets, primarily in cell cycle regulation, for new cancer drug development.

Area of Science:

  • * Molecular Biology
  • * Genomics
  • * Cancer Research

Background:

  • * Chemoprevention offers a promising strategy for controlling major cancers, including those of the colon, breast, prostate, and lung.
  • * While various agents like antioxidants, anti-inflammatory drugs, and phytochemicals show anticancer effects, their precise mechanisms at the gene transcription level require further elucidation.
  • * The advent of DNA microarrays has revolutionized the study of gene expression, enabling the identification of hundreds of differentially expressed genes in response to therapeutic agents.

Purpose of the Study:

  • * To conduct an extensive analysis of key findings from studies investigating potential chemopreventive agents and their impact on global gene expression patterns.
  • * To identify novel cancer drug targets by examining how various compounds modulate gene expression.
  • * To review the utility of DNA microarrays in characterizing and quantifying gene alterations induced by chemopreventive agents across diverse cancer types.

Main Methods:

  • * Comprehensive review of existing literature on chemopreventive agents and their effects on gene expression.
  • * Analysis of studies utilizing DNA microarrays to profile global gene expression changes.
  • * Focus on over 20 compounds, including antioxidants, fatty acids, NSAIDs, phytochemicals, retinoids, selenium, vitamins, and specific agents like oltipraz and resveratrol.

Main Results:

  • * Demonstrated that numerous chemopreventive agents significantly alter gene expression patterns, offering insights into their anticancer mechanisms.
  • * Identified key regulatory genes and pathways, particularly those involved in cell cycle control and apoptosis, as common targets.
  • * Highlighted the effectiveness of DNA microarrays in quantifying gene alterations induced by agents such as resveratrol, selenium, vitamin D, curcumin, and EGCG.

Conclusions:

  • * Chemopreventive agents reprogram gene expression, primarily targeting cell cycle regulatory pathways, to exert their anticancer effects.
  • * The identified gene targets represent potential therapeutic targets for novel cancer drug development.
  • * DNA microarray technology is a valuable tool for discovering and validating these chemoprevention-mediated gene targets across various cancer types.

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