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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
Notch signaling in cancer
Lucio Miele1, Todd Golde, Barbara Osborne
1Breast Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, IL 60153, USA. lmiele@lumc.edu
Current Molecular Medicine
|December 16, 2006
Summary
Notch signaling, crucial for development and homeostasis, has complex roles in human health and disease. Recent research highlights its involvement in cancer, immune, and neurological disorders, with potential therapeutic applications.
Area of Science:
- Molecular Biology
- Cell Biology
- Developmental Biology
- Cancer Research
Background:
- The Notch signaling pathway is an evolutionarily conserved mechanism essential for development and post-natal homeostasis in vertebrates.
- While the core pathway is understood, its intricate cross-talk with other signaling cascades and its context-dependent effects on cell fate are complex.
- Emerging factors like endocytosis, ubiquitin ligases, beta-arrestins, and hypoxia significantly modulate Notch signaling activity.
Purpose of the Study:
- To review recent advancements in understanding Notch signaling.
- To focus on the role of Notch signaling in cancer.
- To discuss the potential clinical implications of targeting Notch signaling in various diseases.
Main Methods:
- Review of recent scientific literature.
- Analysis of structural biology findings on Notch interactions.
- Integration of genomics data on Notch target genes.
Main Results:
- Notch signaling plays critical roles in diverse physiological and pathological processes, including cancer, immune disorders, neurological disorders, and stroke.
- Its function in normal and transformed stem cells is a key area of ongoing investigation.
- Structural biology and genomics are providing deeper insights into Notch pathway mechanisms and target genes.
Conclusions:
- Notch signaling is a significant target for therapeutic intervention, with several Notch-modulating drugs in clinical development.
- Further research into Notch signaling's complex roles, particularly in cancer, holds promise for novel treatment strategies.
- Understanding the intricate regulatory networks of Notch signaling is crucial for harnessing its therapeutic potential.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
03:03mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...