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The Colloidal State

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Updated: Jul 18, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Colloidal microgels in drug delivery applications.

Serguei V Vinogradov¹

¹Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. vinograd@unmc.edu

Current Pharmaceutical Design

|December 16, 2006

Summary

Environmentally responsive colloidal microgels are advanced as intelligent drug carriers. Research focuses on oral delivery, metal-containing microgels for diagnostics and therapeutics, and systemic administration for targeted drug release.

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Published on: February 7, 2021

Area of Science:

Materials Science
Polymer Chemistry
Nanotechnology

Background:

Colloidal microgels are responsive materials increasingly utilized as carriers for drugs and diagnostic agents.
Their crosslinked polymer network acts as a drug depot, offers environmental protection, and allows for modification.
Applications span oral drug delivery, diagnostics, therapeutics, and systemic administration.

Purpose of the Study:

To review recent developments in microgel formulations for oral drug delivery.
To explore the design of metal-containing microgels for combined diagnostic and therapeutic uses.
To discuss advancements in the systemic administration of microgels and novel nanogel systems.

Main Methods:

Review of recent literature on microgel synthesis and applications.
Detailed discussion of novel nanogel drug delivery systems from the authors' laboratory.
Analysis of nanogel synthesis, vectorization, and encapsulation of drugs and macromolecules.

Main Results:

Microgels show promise as versatile drug delivery systems.
Novel nanogels have been developed for encapsulating low molecular weight drugs and biological macromolecules.
Vectorization and targeted delivery strategies are being advanced.

Conclusions:

Recent advancements indicate significant potential for microgels in drug delivery.
Nanogels offer intelligent carrier capabilities, including targeted delivery and triggered release.
Further development is encouraged for sophisticated nanogel-based therapeutic and diagnostic platforms.