Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyaluronan: the Jekyll and Hyde molecule.

Jerome O Cantor1, Priya P Nadkarni

  • 1St. John's University, Jamaica, NY 11439, USA. jocantor@pol.net

Inflammation & Allergy Drug Targets
|December 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elastin as a Therapeutic Target in COPD.

Lung·2026
Same author

Elastolysis in COPD: a Target for Therapy.

Lung·2024
Same author

A 28-day clinical trial of aerosolized hyaluronan in alpha-1 antiprotease deficiency COPD using desmosine as a surrogate marker for drug efficacy.

Respiratory medicine·2021
Same author

COPD Pathogenesis: Finding the Common in the Complex.

Chest·2018
Same author

The Therapeutic Potential of Hyaluronan in COPD.

Chest·2018
Same author

The Effect of Alpha-1 Proteinase Inhibitor on Biomarkers of Elastin Degradation in Alpha-1 Antitrypsin Deficiency: An Analysis of the RAPID/RAPID Extension Trials.

Chronic obstructive pulmonary diseases (Miami, Fla.)·2017

Hyaluronan (HA), a polysaccharide, shows dual roles in inflammation based on size. Larger HA molecules possess anti-inflammatory properties, while smaller fragments can be pro-inflammatory, impacting therapeutic applications.

Area of Science:

  • Biochemistry
  • Immunology
  • Extracellular Matrix Biology

Background:

  • Hyaluronan (HA) is a polysaccharide found in the extracellular matrix.
  • Traditionally viewed as inert, HA is now recognized for its role in modulating inflammation.
  • HA's biological effects are dependent on its molecular size.

Purpose of the Study:

  • To explore the therapeutic potential of Hyaluronan (HA) as an anti-inflammatory agent.
  • To address the challenges posed by HA's size-dependent, dichotomous effect on inflammation.
  • To investigate strategies for optimizing HA's therapeutic efficacy in disease treatment.

Main Methods:

  • Review of existing literature on Hyaluronan's role in inflammation.
  • Experimental use of HA in treating induced lung disease models.

Related Experiment Videos

  • Discussion of methods to overcome HA degradation and maximize therapeutic benefits.

    • Main Results:

    • Hyaluronan's anti-inflammatory effects are associated with larger molecular sizes.
    • Smaller HA fragments exhibit pro-inflammatory properties.
    • Therapeutic administration of HA faces challenges due to potential breakdown into harmful smaller fragments.

    Conclusions:

    • The size of Hyaluronan critically determines its impact on the inflammatory response.
    • Strategies are needed to stabilize therapeutic HA and prevent its degradation into pro-inflammatory fragments.
    • Further research is warranted to harness HA's anti-inflammatory potential for treating various diseases, including lung conditions.