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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Long-term survival in patients treated with cardiac resynchronization therapy: a 3-year follow-up study from the

Maurizio Gasparini1, Maurizio Lunati, Massimo Santini

  • 1IRCCS Istituto Clinico Humanitas, Rozzano (Milan), Italy. maurizio.gasparini@humanitas.it

Pacing and Clinical Electrophysiology : PACE
|December 16, 2006
PubMed

Insights

Cardiac resynchronization therapy (CRT) improves heart function long-term in real-world patients. Ischemic heart disease and severe heart failure predict worse outcomes, but CRT benefits persist.

Area of Science:

  • Cardiology
  • Heart Failure Management
  • Medical Device Therapy

Background:

  • Limited data exists on long-term cardiac resynchronization therapy (CRT) survival outside clinical trials.
  • Real-world effectiveness and long-term outcomes of CRT require further investigation.

Purpose of the Study:

  • To evaluate the survival rates of patients receiving CRT in routine clinical practice.
  • To assess the sustained impact of CRT on clinical status and echocardiographic parameters over time.

Main Methods:

  • An observational registry of 317 consecutive patients with implanted CRT devices was analyzed.
  • Minimum follow-up was 2 years, with mortality data collected via hospital records and direct contact.

Main Results:

  • Overall mortality was 26% during the study period; ischemic patients had higher mortality (14% vs. 8%).
  • Ischemic etiology and New York Heart Association (NYHA) class IV were key predictors of mortality.
  • CRT benefits, including improved NYHA class, ejection fraction, and reduced QRS duration, were sustained long-term.

Conclusions:

  • Long-term (3-year) follow-up showed a 10% annual mortality rate after CRT.
  • Worse outcomes in ischemic patients were linked to progressive heart failure.
  • CRT demonstrated persistent benefits in clinical function and echocardiographic measures at long-term follow-up.
Abstract

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