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Related Experiment Videos

Coated microneedles for transdermal delivery.

Harvinder S Gill1, Mark R Prausnitz

  • 1Wallace H Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, Atlanta, GA 30332-0100, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 16, 2006
PubMed
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This study developed a versatile microneedle coating method for delivering proteins, DNA, viruses, and microparticles. The process ensures uniform coatings for minimally invasive transdermal delivery.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Microneedles offer minimally invasive delivery of proteins and DNA.
  • Existing microneedle coating methods lack detailed studies on applicability and uniformity.
  • A need exists for a versatile and controlled coating process for various molecules and particles.

Purpose of the Study:

  • To develop a simple, versatile, and controlled microneedle coating process.
  • To achieve uniform coatings on microneedles (single and arrays).
  • To establish the breadth of molecules and particles that can be coated.

Main Methods:

  • Fabrication of microneedles from stainless steel sheets.
  • Development of a micron-scale dip-coating process with a GRAS (Generally Recognized As Safe) formulation.

Related Experiment Videos

  • Coating of various substances including proteins (calcein, bovine serum albumin), vitamin B, plasmid DNA, modified vaccinia virus, and microparticles (1-20 µm).

    • Main Results:

    • Uniform coatings were reliably produced on both individual microneedles and arrays.
    • The process successfully coated a diverse range of molecules and particles.
    • Coatings were localized to needle shafts, dissolved rapidly (within 20s) in skin, and were delivered effectively without wiping off during insertion.

    Conclusions:

    • A simple, versatile, and controllable microneedle coating method was successfully developed.
    • This method enables the rapid delivery of proteins, DNA, viruses, and microparticles into the skin.
    • The findings support the potential of microneedles for advanced transdermal therapeutic applications.