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Updated: Jul 18, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and
1Department of Dermatology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan. asadah@naramed-u.ac.jp
Abstract:
Hypersensitivity to mosquito bites (HMB) is characterized by intense local skin reactions and systemic symptoms, such as high fever, lymphadenopathy and hepatosplenomegaly. Half of the patients reported died of hemophagocytic syndrome or lymphocyte proliferative disorders. Clinical and laboratory studies have revealed that HMB occurs in association with natural killer (NK) cell lymphocytosis related to chronic Epstein-Barr virus (EBV) infection. Recent studies have clarified the unique pathogenic mechanism of this mysterious disease, and demonstrated the close relationship between HMB and EBV-carrying NK cell lymphocytosis; i.e., CD4(+) T cells from the patients markedly responded to mosquito salivary gland extracts, and the CD4(+) T cells stimulated by mosquito bites may play a key role in the development of HMB and NK cell oncogenesis via the induction of EBV reactivation and EBV-oncogene expression, respectively.
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