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Elevated serum uric acid levels impair coronary microvascular function in patients with idiopathic dilated

Hakan Gullu1, Dogan Erdogan, Mustafa Caliskan

  • 1Baskent University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey. gulluhakan@hotmail.com

European Journal of Heart Failure
|December 16, 2006
PubMed

Insights

In patients with idiopathic dilated cardiomyopathy, higher serum uric acid levels are linked to reduced coronary flow reserve (CFR), indicating impaired microvascular function. This suggests uric acid may be a predictor of coronary microvascular dysfunction in IDC.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biochemistry

Background:

  • Idiopathic dilated cardiomyopathy (IDC) is associated with impaired coronary flow reserve (CFR).
  • Elevated serum uric acid levels have been observed in patients with IDC.
  • The relationship between uric acid and coronary microvascular dysfunction in IDC requires further investigation.

Purpose of the Study:

  • To investigate the correlation between serum uric acid levels and the degree of coronary microvascular dysfunction in patients with IDC.
  • To determine if uric acid is an independent predictor of CFR in IDC.

Main Methods:

  • Serum uric acid levels were measured in 29 patients diagnosed with IDC.
  • Transthoracic echocardiography was performed to assess CFR in all participants.
  • Patients were stratified into lower and higher CFR groups based on the median CFR value.

Main Results:

  • Serum uric acid levels were significantly higher in the lower CFR group compared to the higher CFR group (7.59±2.56 vs 4.80±0.80 mg/dL, P=0.000).
  • A significant inverse correlation was found between CFR and serum uric acid levels (r=-0.570, P=0.001).
  • Logistic regression analysis identified serum uric acid level as the sole independent predictor of CFR (B=-1080, P=0.015).

Conclusions:

  • Serum uric acid levels are negatively associated with coronary flow reserve in patients with idiopathic dilated cardiomyopathy.
  • Elevated uric acid may indicate or contribute to coronary microvascular dysfunction in IDC.
  • Uric acid is a potential independent predictor of impaired CFR in this patient population.

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