Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial progenitor cells.

Brendan Doyle1, Pat Metharom, Noel M Caplice

  • 1Molecular Medicine Programm, Mayo Clinic, Rochester, Minnesota, USA.

Endothelium : Journal of Endothelial Cell Research
|December 16, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adipose Tissue in SARS-CoV-2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update.

Obesity (Silver Spring, Md.)·2025
Same author

Leptospira interrogans serovar Copenhageni infection and exudative glomerulonephritis in rehabilitated gray seals (Halichoerus grypus) and harbor seals (Phoca vitulina) in Ireland.

Veterinary microbiology·2025
Same author

Clinical benefit and cost of plasma-first next-generation sequencing in patients with newly diagnosed advanced non-small cell lung cancer in Ireland: The PLAN study.

European journal of cancer (Oxford, England : 1990)·2025
Same author

Artificial intelligence-assisted left ventricular global longitudinal strain assessment in patients with acute myocardial infarction: a RESUS-AMI trial sub-analysis.

The international journal of cardiovascular imaging·2025
Same author

Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome.

JACC. Basic to translational science·2025
Same author

Phenotypic outcomes of PKD1 compared with non-PKD1 genetically confirmed autosomal dominant polycystic kidney disease.

Journal of nephrology·2025
Same journal

Melanoma Cell Invasive and Metastatic Potential Correlates with Endothelial Cell Reorganization and Tenascin Expression.

Endothelium : journal of endothelial cell research·2012
Same journal

31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel constructs as an enabling platform technology: II. The effect of anti-inflammatory drugs on phosphometabolite levels.

Endothelium : journal of endothelial cell research·2008
Same journal

31P magnetic resonance spectroscopy of endothelial cells grown in three-dimensional matrigel construct as an enabling platform technology: I. The effect of glial cells and valproic acid on phosphometabolite levels.

Endothelium : journal of endothelial cell research·2008
Same journal

p66Shc deletion confers vascular protection in advanced atherosclerosis in hypercholesterolemic apolipoprotein E knockout mice.

Endothelium : journal of endothelial cell research·2008
Same journal

Interaction of estrogen and tumor necrosis factor alpha in endothelial cell migration and early stage of angiogenesis.

Endothelium : journal of endothelial cell research·2008
Same journal

Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro.

Endothelium : journal of endothelial cell research·2008
See all related articles

Endothelial progenitor cells (EPCs) play a key role in blood vessel formation in adults, offering potential for regenerative therapies. Further research is needed to confirm their efficacy and understand their origins.

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Endothelial progenitor cells (EPCs) are crucial for postnatal vasculogenesis and angiogenesis.
  • Once thought to be embryonic, EPCs are now known to differentiate in adults.
  • EPCs are found in peripheral blood, bone marrow, and other tissues, suggesting broad physiological roles.

Purpose of the Study:

  • To explore the significance of EPCs in human health and disease.
  • To investigate the potential of EPCs in regenerative therapies.
  • To highlight current challenges in EPC research.

Main Methods:

  • Isolation and characterization of EPCs from various human tissues.
  • Assessment of EPC function in angiogenesis and vascular repair models.

Related Experiment Videos

  • Review of preclinical and early clinical trial data for EPC-based therapies.

    • Main Results:

    • EPCs contribute to neovascularization and vascular repair in adults.
    • EPCs exhibit vasculoprotective functions.
    • Early trials show promise for EPC-based regenerative medicine.

    Conclusions:

    • EPCs are vital for adult vascular maintenance and repair.
    • EPCs hold significant therapeutic potential for vascular diseases.
    • Further research is required to elucidate EPC ontogeny, precise roles, and validate therapeutic efficacy through rigorous clinical trials.