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Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
Published on: September 27, 2013
Promoting vascular regeneration as an alternative to conventional angioplasty-based intervention
Annemarie M Noordeloos1, Thomas Soullié, Henricus J Duckers
1Molecular Cardiology Laboratory, Erasmus University Medical Center, Rotterdam, The Netherlands.
Abstract:
Technologies in interventional Cardiology have evolved from balloon to mechanical ablation, atherectomy, stenting, and brachytherapy to current drug eluting interventional strategies. New challenges are to develop techniques that not only prevent restenosis, but also promote vascular and endothelial healing after (balloon) injury. Endothelial healing approaches range from preventing endothelial injury to restoring endothelial function and reendothelialization by pharmacotherapy and cell therapy. These novel healing strategies warrant further exploration as they may represent an alternative to drug-eluting stent approaches.
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