Related Experiment Video
Updated: Jul 18, 2026
Fast and Accurate Exhaled Breath Ammonia Measurement
Published on: June 11, 2014
Validation study of fractional exhaled nitric oxide measurements using a handheld monitoring device
Michelle Gill1, Gavin R Graff, Alan J Adler
1The Department of Emergency Medicine, Loma Linda University School of Medicine, 11234 Anderson Street, Loma Linda, CA 92354, USA. mgill@ahs.llumc.edu
Abstract:
We tested reproducibility of exhaled nitric oxide (FE(NO)) and inter-operator handling when measured with a handheld device, NIOX MINO. We enrolled 20 volunteers using a priori goals of acceptable reproducibility to be mean within-subject standard deviation less than 3 parts per billion (ppb) for FE(NO) measurements less than 30 ppb, and mean coefficient of variation less than 10% for FE(NO) measurements more than 30 ppb. Seventeen subjects with measurements less than 30 ppb displayed a mean standard deviation of 1.15, and 3 subjects with FE(NO) more than 30 ppb had a mean coefficient of variation of 2.4%. We conclude that NIOX MINO demonstrates excellent reproducibility for all ranges of FE(NO).
