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Related Experiment Video

Updated: Jul 18, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

TNF-alpha neutralization ameliorates obstruction-induced renal fibrosis and dysfunction.

K K Meldrum1, R Misseri, P Metcalfe

  • 1Department of Urology, Indiana University, Indianapolis, IN 46202, USA. kmeldrum@iupui.edu

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|December 16, 2006
PubMed
Summary

Tumor necrosis factor-alpha (TNF-alpha) drives kidney fibrosis and dysfunction following upper urinary tract obstruction. Neutralizing TNF-alpha with PEG-sTNFR1 effectively reduced these detrimental effects in a rat model.

Related Experiment Videos

Last Updated: Jul 18, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Area of Science:

  • Nephrology
  • Immunology
  • Pathophysiology

Background:

  • Upper urinary tract obstruction causes tubulointerstitial fibrosis and renal dysfunction.
  • The role of Tumor Necrosis Factor-alpha (TNF-alpha) in this process is not fully understood.

Purpose of the Study:

  • To investigate the contribution of TNF-alpha to obstruction-induced renal fibrosis and dysfunction.
  • To evaluate the therapeutic potential of TNF-alpha neutralization.

Main Methods:

  • Male Sprague-Dawley rats underwent unilateral ureteral obstruction or sham surgery.
  • Rats received either vehicle or a pegylated form of soluble TNF receptor type 1 (PEG-sTNFR1).
  • Kidney tissues and glomerular filtration rate were analyzed for markers of fibrosis and renal function.

Main Results:

  • Renal obstruction increased TNF-alpha, TGF-beta1, collagen deposition, alpha-SMA, angiotensinogen, and interstitial volume, leading to renal dysfunction.
  • PEG-sTNFR1 treatment significantly attenuated these obstruction-induced changes.
  • Glomerular filtration rate was preserved in rats treated with PEG-sTNFR1.

Conclusions:

  • TNF-alpha plays a critical role in mediating renal fibrosis and dysfunction following upper urinary tract obstruction.
  • Neutralization of TNF-alpha represents a promising therapeutic strategy for obstructive nephropathy.