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Histocompatible embryonic stem cells by parthenogenesis.

Kitai Kim1, Paul Lerou, Akiko Yabuuchi

  • 1Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA.

Science (New York, N.Y.)
|December 16, 2006
PubMed
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Parthenogenetically derived embryonic stem (pES) cells offer a source of histocompatible tissues for transplantation. Selected pES cells, matched for major histocompatibility complex antigens, successfully engrafted in mice.

Area of Science:

  • Stem cell biology
  • Immunology
  • Reproductive biology

Background:

  • Genetically matched pluripotent stem cells are crucial for transplantation to avoid immune rejection.
  • Parthenogenesis offers a method to generate embryonic stem cells without fertilization.

Purpose of the Study:

  • To investigate the potential of parthenogenetically derived embryonic stem (pES) cells as a source of histocompatible tissues.
  • To characterize pES cells for major histocompatibility complex (MHC) antigen compatibility.

Main Methods:

  • Parthenogenetic activation of murine oocytes followed by interruption of meiosis.
  • Isolation, genotyping, and characterization of pES cells.
  • Differentiation of pES cells into various tissues.
  • Engraftment of differentiated tissues into MHC-matched immunocompetent mouse recipients.

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Main Results:

  • pES cells were successfully isolated and genotyped.
  • Selected pES cells expressed the full complement of oocyte donor MHC antigens.
  • Differentiated tissues derived from these pES cells engrafted successfully in MHC-matched recipients.

Conclusions:

  • Selected pES cells can serve as a source of histocompatible tissues for transplantation.
  • This approach holds promise for generating immune-compatible cell and tissue replacements.