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Murine Model of CD40-activation of B cells
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Published on: March 5, 2010

Development of murine B cell subpopulations

R R Hardy1

  • 1I.C.R., Fox Chase Cancer Center, Philadelphia, PA 19111.

Seminars in Immunology
|May 1, 1990
PubMed

The generation of diverse B cell subpopulations in the mouse is the subject of considerable current interest. In this review, I first describe a general framework for antigen-independent B cell differentiation in the adult bone marrow including results from in vitro culture systems. In following sections, effects on B cell development in several immunodeficient strains and transgenic lines are presented. Next, the CD5+ B cell subpopulation is covered in some depth, including data on development, physiology and repertoire selection. Finally, another selected population, memory B cells, together with their likely origins in the germinal center are discussed.

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