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Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
Published on: September 16, 2022
Immune reactions and allergy in experimental anisakiasis
Sung-Weon Cho1, Haneul Nari Lee
1Department of Parasitology, Korea University College of Medicine, Seoul, Korea. csw0419@korea.ac.kr
Abstract:
The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions in the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans.
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