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Left ventricular hypertrophy in patients with renal artery stenosis

S Wu1, N Polavarapu, G A Stouffer

  • 1Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina 27599-7075, USA.

The American Journal of the Medical Sciences
|December 16, 2006
PubMed

Insights

Left ventricular hypertrophy (LVH) affects 27% of patients with renal artery stenosis (RAS). However, neither blood pressure nor stenosis severity predicted LVH in this study population.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Diagnostics

Background:

  • Left ventricular hypertrophy (LVH) is more common in renal artery stenosis (RAS) patients than those with essential hypertension.
  • Predictors of LVH in RAS patients remain unclear.

Purpose of the Study:

  • To investigate factors associated with LVH in patients with unilateral RAS.

Main Methods:

  • Sixty-six patients with unilateral RAS and interpretable ECGs were analyzed.
  • LVH was assessed using Cornell voltage-duration product and Sokolow-Lyon voltage criteria.
  • Correlation analysis was performed between LVH and blood pressure, stenosis severity, and pressure gradients.

Main Results:

  • LVH was present in 27% of patients.
  • No significant association was found between LVH and intra-aortic blood pressure (P=0.37).
  • LVH was not correlated with stenosis severity (P=0.34) or translesional pressure gradient (P=0.60).

Conclusions:

  • ECG-defined LVH is prevalent in unilateral RAS patients.
  • Blood pressure and RAS severity do not appear to predict LVH in this cohort.

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