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Magnetic resonance imaging of intercranial plasmocytic granuloma
Abstract:
The objective of this study is to determine characteristic magnetic resonance imaging (MRI) features of intracranial plasmocytic granulomas. Pathological confirmation of three patients with intracranial pathologically confirmed plasmocytic granuloma are presented. Clinical records as well pre- and postgadolinium-enhanced images from each patient are reviewed. The location of the abnormalities is compared with previous reported cases of plasmocytic granulomas, to determine if there is a characteristic finding in this disense. The predominance of this abnormality in the pediatric and young adult patient was striking. On T(1)-weighted MRI, plasmocytic granulomas appear as hypointense lesions, with isointense appearance on T(2) images, and significant, variable patterns of enhancement after the infusion of gadolinium. Typically, the lesion is infiltrating, and causes little mass effect. A dural based lesion, as well as a sellar region abnormality and an infiltrating cortical lesion with little mass effect in the pediatric or young adult age group may lead the observer to suspect the diagnosis of plasmocytic granuloma.
Insights
Magnetic resonance imaging (MRI) reveals characteristic features of intracranial plasmocytic granulomas, particularly in pediatric and young adult patients. These lesions typically appear hypointense on T1-weighted and isointense on T2-weighted MRI, with variable gadolinium enhancement.
Area of Science:
- Neurology
- Radiology
- Pathology
Background:
- Intracranial plasmacytic granulomas are rare tumors.
- Characteristic imaging features are not well-defined.
Purpose of the Study:
- To determine the characteristic magnetic resonance imaging (MRI) features of intracranial plasmacytic granulomas.
- To compare findings with previously reported cases.
Main Methods:
- Retrospective review of three pathologically confirmed cases of intracranial plasmacytic granuloma.
- Analysis of clinical records and pre- and postgadolinium-enhanced MRI scans.
- Comparison of lesion location with existing literature.
Main Results:
- Lesions predominantly affect pediatric and young adult patients.
- On T1-weighted MRI, lesions are hypointense; on T2-weighted MRI, they are isointense.
- Significant and variable gadolinium enhancement is observed.
- Lesions are typically infiltrating with minimal mass effect.
- Common locations include dural-based, sellar region, and cortical.
Conclusions:
- Characteristic MRI findings, including lesion appearance, enhancement patterns, and location, can suggest the diagnosis of intracranial plasmacytic granuloma.
- The predilection for pediatric and young adult populations is a key diagnostic clue.
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