Related Experiment Video
Updated: Jul 18, 2026

04:05
A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Retractile mesenteritis presenting as protein-losing gastroenteropathy
Bahe Rajendran1, Donald R Duerksen
1Department of Medicine, University of Manitoba, Winnipeg.
Summary
Retractile mesenteritis, a rare inflammatory condition, can cause protein-losing enteropathy. Diagnosis involves stool alpha1-antitrypsin clearance, and treatment may include immunosuppressants.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Retractile mesenteritis is a rare idiopathic condition involving mesenteric adipose tissue inflammation.
- Common symptoms include abdominal pain and palpable masses.
Observation:
- A 68-year-old man presented with peripheral edema and hypoalbuminemia.
- Protein-losing enteropathy was confirmed via stool alpha1-antitrypsin clearance.
- Retractile mesenteritis was diagnosed during laparoscopy.
Findings:
- This case highlights retractile mesenteritis presenting atypically with edema and hypoalbuminemia.
- Stool alpha1-antitrypsin clearance is crucial for diagnosing protein-losing enteropathy.
Implications:
- Gastroenterologists should consider protein-losing enteropathy in patients with unexplained edema or hypoalbuminemia.
- Various treatments exist for retractile mesenteritis, including corticosteroids and immunosuppressants.
Related Concept Videos
Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Protein Absorption
Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...