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Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer
C Pesce1, M J Merino, J T Chambers
1Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892.
Abstract:
Three cases of poorly differentiated endometrial adenocarcinoma showing trophoblast-like differentiation are reported. The multinucleated, syncytiotrophoblast-like cells were strongly positive for beta-human chorionic gonadotropin (beta-HCG) by immunohistochemical study. High levels of beta-HCG were also present in the patients' serum, but dropped significantly after treatment. The patients had an unusually rapid and progressive clinical course with widespread dissemination and death by tumor.
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