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In Vivo SiRNA Transfection and Gene Knockdown in Spinal Cord via Rapid Noninvasive Lumbar Intrathecal Injections in Mice
Published on: March 22, 2014
[Injection therapy of the spine without imaging]
1Institut für Wirbelsäulenforschung an der Ruhr-Universität Bochum, 44787, Viktoriastrasse 66-70 , Bochum, Germany. info@dr-theodoridis.de
Der Orthopade
|December 16, 2006
Summary
Nerve root blocks and epidural injections can treat degenerative spine diseases without imaging, reducing radiation exposure. This technique uses anatomical landmarks to safely relieve pain and inflammation from spinal conditions.
Area of Science:
- Pain management
- Neurosurgery
- Radiology
Context:
- Degenerative spine diseases often require conservative treatment.
- Nerve root blocks and epidural perineural injections are key conservative treatments.
- Repetitive imaging for spinal conditions poses cumulative radiation risks, especially for younger patients.
Purpose:
- To advocate for and describe image-free spinal injections for degenerative spine diseases.
- To highlight the safety and efficacy of using topographic anatomical landmarks for these procedures.
- To explain the mechanism of action for nerve root desensitization and inflammation reduction.
Summary:
- Spinal injections, including nerve root blocks and epidural perineural injections, can be performed safely without imaging by utilizing topographic anatomical landmarks.
- This approach mitigates risks associated with cumulative ionizing radiation from repeated imaging, particularly crucial for younger individuals with recurrent degenerative spine conditions.
- The procedure involves local anesthetics to desensitize nerve roots and steroids to reduce inflammation, effectively transitioning symptomatic deformities to an asymptomatic state.
Impact:
- Reduces patient exposure to ionizing radiation, enhancing safety in conservative spine treatment.
- Provides a viable, training-dependent alternative to image-guided injections, potentially lowering healthcare costs.
- Offers effective pain relief and functional improvement for patients with degenerative spine diseases.
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