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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Reactivation of hepatitis in a bladder cancer patient receiving chemotherapy
Hiroshi Higashiyama1, Toru Harabayashi, Nobuo Shinohara
1Department of Renal and Genito-urinary Surgery, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Sapporo, Japan.
Abstract:
Reactivation of hepatitis is a serious complication of chemotherapy in hepatitis B virus (HBV) carriers. There are many reports of this in lymphoma patients but few in urological cancer patients. A 59-year-old woman with bladder cancer who was an HBV carrier developed severe liver dysfunction after 2 cycles of chemotherapy. The diagnosis was reactivation of hepatitis. She improved with administration of lamivudine with a steroid and is currently well without disease. Care should be taken about the risk of reactivation when performing chemotherapy in HBV carriers and prophylaxis by lamivudine should be considered.
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