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Updated: Jul 18, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Low-compliance, volume-controlled, high-frequency positive-pressure ventilation versus conventional ventilation
R B Smith1, S Swartzman, U H Sjostrand
1Department of Anesthesiology, The University of Texas Health Science Center, San Antonio, TX 78284-7838, USA.
Abstract:
Low-compliance, volume-controlled, high-frequency positive-pressure ventilation (HFPPV) was compared to conventional intermittent positive-pressure ventilation (IPPV) immediately before and after surgery in a series of ten patients who underwent coronary artery bypass grafting (CABG). Direct and indirect hemodynamic and respiratory variables were recorded and calculated. All patients were adequately ventilated with either HFPPV or IPPV. No significant differences in hemodynamic stability were noted either before or after cardiopulmonary bypass (CPB). Airway pressures were lowered significantly by HFPPV as compared to IPPV. This may be useful in cases in which increased airway pressure might be harmful due to decreased venous return and cardiac output (CO).
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