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Updated: Jul 18, 2026

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

[Listeria-induced host cellular actin cytoskeleton rearrangement and phospholipase D]

Li Han1, Xu-Qin Wu, Yu-Fen Meng

  • 1Chinese PLA Center for Disease Control & Prevention, Beijing 100071, China. Lihan@301hospital.com

Wei Sheng Wu Xue Bao = Acta Microbiologica Sinica
|December 19, 2006
PubMed

Insights

Phospholipase D (PLD) regulates actin cytoskeleton rearrangement, crucial for pathogen invasion and macrophage phagocytosis. Understanding PLD

Area of Science:

  • Cell Biology
  • Microbiology
  • Biochemistry

Context:

  • Pathogen entry into host cells and macrophage phagocytosis rely on actin cytoskeleton dynamics.
  • Monomeric GTPases and associated proteins precisely control these cellular rearrangements.
  • Phosphatidylinositol-specific phospholipase D (PLD) is a key signaling molecule interacting with the actin cytoskeleton.

Purpose:

  • To investigate the function of PLD in regulating Listeria-induced actin cytoskeleton rearrangement during infection.
  • To elucidate the molecular mechanisms underlying bacterial-host interactions.

Summary:

  • PLD regulates actin cytoskeleton rearrangement, essential for phagocytosis and pathogen invasion.
  • PLD interacts with cofilin, a key regulator of actin dynamics, influencing Listeria infection.
  • This study challenges the understanding of PLD's role in Listeria-induced cytoskeletal changes.

Impact:

  • Provides deeper insights into PLD's role in infection and inflammation.
  • Enhances understanding of bacterial-host molecular interactions.
  • Contributes to dissecting the complex signaling pathways in host-pathogen dynamics.

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