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Fluorine-18 labeling of peptides and proteins

H J Wester1, M Schottelius

  • 1Nuklearmedizinische Klinik und Poliklinik und Institut für Radiochemie, Technische Universität Müchen, Germany. H.J.Wester@lrz.tum.de

Ernst Schering Research Foundation Workshop
|December 19, 2006
PubMed

Insights

Peptides are emerging as crucial drug candidates, with 50% of future clinical trials expected to involve them. Research is advancing peptide-based therapies and diagnostic tracers for various diseases, including cancer.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Peptides are increasingly recognized for their therapeutic potential, particularly in targeting somatostatin-2 receptor-positive neuroendocrine tumors.
  • Advancements in understanding peptide hormone receptor expression in cancers are driving research into novel peptide-based therapeutics and diagnostics.
  • Peptides are projected to constitute approximately 50% of drugs entering clinical trials in the coming years.

Purpose of the Study:

  • To provide an overview of methods and strategies for the 18F-labeling of peptides and proteins.
  • To highlight the growing importance of bioactive peptides in disease targeting and molecular imaging.
  • To discuss the potential of peptides in bridging diagnostic imaging and therapeutic applications.

Main Methods:

  • Review of current research in peptide drug discovery and development.
  • Exploration of techniques for identifying peptide ligands, including phage display.
  • Summary of methodologies for incorporating fluorine-18 (18F) into peptides and proteins for imaging.

Main Results:

  • Peptide hormone receptor profiling in human cancers is accelerating research on targeted peptide binders.
  • Genomics and proteomics are identifying new disease-associated molecular targets for peptide-based interventions.
  • 18F-labeled peptides show promise as diagnostic tracers and therapeutic agents.

Conclusions:

  • Bioactive peptides are poised to become a significant class of molecular imaging tracers and therapeutic agents.
  • The development of targeted peptide ligands is crucial for advancing precision medicine.
  • 18F-labeling techniques are essential for realizing the full potential of peptides in clinical applications.

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