Related Experiment Video
Updated: Jul 18, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
A unique simultaneous occurrence of paratracheal granular cell tumor and papillary thyroid carcinoma
Renato Colella1, Angelo Sidoni, Guido Bellezza
1Institute of Pathological Anatomy and Histology, Perugia University, Perugia, Italy. Renato.Colella@tin.it
Abstract:
We report an unusual case of granular cell tumor in the paratracheal region detected during total thyroidectomy for papillary carcinoma and clinically misdiagnosed as tracheal infiltration of thyroid neoplasia. Histologically, the granular cell tumor had infiltrated the thyroid gland close behind the papillary carcinoma. At immunohistochemical investigation, the cells showed diffuse positivity for S-100, neuron-specific enolase, and CD68, and surprisingly, positivity also for galectin-3 and HBME-1. A granular cell tumor should also be considered in the cytologic differential diagnosis of the thyroid and paratracheal nodules.
Related Concept Videos
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Graves Disease II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Hyperthyroidism I: Introduction
Graves' Disease I: Introduction