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The unfolded protein response.

Martin Schröder1

  • 1School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, United Kingdom. martin.schroeder@durham.ac.uk

Molecular Biotechnology
|December 19, 2006
PubMed
Summary
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The unfolded protein response (UPR) is a cellular stress pathway. This review details UPR signaling, which manages endoplasmic reticulum stress and cell fate.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Endoplasmic reticulum (ER) stress arises from misfolded proteins.
  • The unfolded protein response (UPR) is a protective cellular mechanism.

Purpose of the Study:

  • To review the signal transduction pathways of the UPR.
  • To summarize current knowledge on ER stress response.

Main Methods:

  • Literature review of UPR signaling pathways.
  • Analysis of adaptive responses to ER stress.

Main Results:

  • UPR activates adaptive responses: chaperone expression, phospholipid synthesis, translation attenuation, ER-associated degradation, and antioxidant response.
  • Severe ER stress triggers UPR-induced apoptosis for cell elimination.

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Conclusions:

  • The UPR is a critical network for maintaining ER homeostasis.
  • Understanding UPR signaling is key to addressing diseases linked to ER stress.