Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Data Validation01:15

Data Validation

Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
Data Validation01:03

Data Validation

Data validation is an essential part of a comprehensive assessment. Validation is confirming or verifying and opening the door to gathering more assessment data as it clarifies vague or unclear data. The process of checking and verifying the collected information is called data validation. The primary purpose of data validation is to ensure data is as free from error, bias, and misinterpretation as possible.
Nursing assessment guides are generally based on holistic models rather than medical...
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ<sub>1</sub> Receptor Antagonist Clinical Candidate for the Treatment of Pain.

Journal of medicinal chemistry·2020
Same author

Co-crystals as a new approach to multimodal analgesia and the treatment of pain.

Journal of pain research·2019
Same author

Brain cytokines and disease.

Acta neuropsychiatrica·2016
Same author

Nanoliter high-throughput RT-qPCR: a statistical analysis and assessment.

BioTechniques·2009
Same author

Levels of mRNA coding for alpha-, beta-, and gamma-synuclein in the brains of newborn, juvenile, and adult rats.

Journal of molecular neuroscience : MN·2006
Same author

Nanoliter high throughput quantitative PCR.

Nucleic acids research·2006

Related Experiment Video

Updated: Jul 18, 2026

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Considerations for target validation and industrial approaches.

Carlos R Plata-Salamán1, Sergey E Ilyin

  • 1Global External Research and Development, Lilly Research Laboratories, Lilly Corporate Centre, Indianapolis, IN, USA.

Methods in Molecular Biology (Clifton, N.J.)
|December 19, 2006
PubMed
Summary

Target validation connects molecular targets to biological responses for drug development. This process integrates multiple technologies to understand target mechanisms and therapeutic potential.

Related Experiment Videos

Last Updated: Jul 18, 2026

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Area of Science:

  • Biomedical Research
  • Pharmacology
  • Molecular Biology

Background:

  • Target validation is crucial for understanding health and disease by linking molecular targets to physiological responses.
  • Current methods necessitate integrating diverse approaches to elucidate the mechanistic link between molecular targets and biological processes.
  • Drug target validation is a key aspect, focusing on therapeutic applications.

Purpose of the Study:

  • To define the essential role and evolving methodologies of target validation in biomedical research.
  • To highlight the integration of multiple technologies for mechanistic understanding.
  • To emphasize the connection between target validation and the development of novel therapeutics.

Main Methods:

  • Integration of complementary approaches and technologies.
  • Analysis of molecular target modulation and its effects.
  • Review of current state-of-the-art in target validation.

Main Results:

  • Target validation requires a multidisciplinary approach for mechanistic insight.
  • The process establishes the foundation for drug target validation.
  • Emerging therapeutic agents and delivery systems are expanding the scope of target validation.

Conclusions:

  • Target validation is a dynamic field essential for advancing therapeutic interventions.
  • The coevolution of target validation and drug development drives innovation.
  • Future directions involve targeting previously inaccessible molecular entities.