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Updated: Jul 18, 2026

A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training

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Naltrexone-assisted rapid methadone discontinuation: a pilot study.

Xavier Camarasa¹, Yasser Khazaal, Jacques Besson

¹Centro de Salud Miguel Servet Alcorcón, Alcorcón, Spain.

European Addiction Research

|December 19, 2006

Summary

This study tested a 3-day accelerated methadone detoxification using naltrexone. While it shortened withdrawal, symptoms reappeared in two phases, suggesting complex management needs for methadone patients.

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A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

Area of Science:

Addiction Medicine
Pharmacology

Background:

Methadone discontinuation is challenging, with slow downtitration leading to high dropout rates.
Ultra-rapid opiate detoxification is costly and poses risks for methadone patients.

Purpose of the Study:

To evaluate a novel 3-day accelerated detoxification protocol for methadone-substituted patients using a specific naltrexone dose.

Main Methods:

A 10-patient cohort underwent a 3-day accelerated detoxification procedure.
Naltrexone was administered to accelerate the detoxification process.
Withdrawal symptoms were monitored and managed with supportive medications.

Main Results:

The 3-day protocol successfully shortened the overall withdrawal syndrome.
A two-phase withdrawal pattern emerged: initial symptoms possibly due to naltrexone antagonism, followed by later symptoms linked to decreasing methadone levels.
The withdrawal syndrome was generally controlled by the medications used.

Conclusions:

This accelerated detoxification shows promise for shortening withdrawal in methadone patients.
The observed two-phase symptom course highlights the need for careful monitoring and potential adjustments to manage both naltrexone effects and falling methadone levels.
Further research is needed to optimize this rapid detoxification method for methadone-substituted individuals.