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Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients
Published on: August 2, 2024
Corneal toxicity from topical ocular and systemic medications
1Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239-4197, USA. eyedrug@ohsu.edu
Cornea
|December 19, 2006
Summary
Many common medications can harm the cornea, causing drug-related corneal toxicity. Ophthalmologists must recognize these risks associated with drugs like antibiotics, steroids, and chemotherapy agents.
Area of Science:
- Ophthalmology
- Pharmacology
- Toxicology
Background:
- Corneal toxicity is a significant concern in ocular health.
- Understanding drug-induced ocular side effects is crucial for patient care.
Purpose of the Study:
- To review known adverse effects on the cornea from various medication classes.
- To present new data on previously unreported cases of drug-related corneal toxicity.
Main Methods:
- Conducted a Medline literature review.
- Analyzed case reports from the World Health Organization, Food and Drug Administration, and National Registry of Drug-Induced Ocular Side Effects.
Main Results:
- Identified numerous drug classes associated with corneal toxicity, including aminoglycosides, bisphosphonates, chemotherapy agents, cyclooxygenase-2 inhibitors, fluoroquinolones, glaucoma eye drops, topical iodine, nonsteroidal anti-inflammatory eye drops, preservatives, retinoids, topical anesthetics, topical steroids, and herbal medications.
- Highlighted that these effects can occur in susceptible patients.
Conclusions:
- Ophthalmologists must be aware of the potential for corneal toxicity from commonly prescribed medications.
- Emphasizes the need for vigilance in identifying and managing drug-induced corneal damage.
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