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Updated: Jul 18, 2026
Retroductal Nanoparticle Injection to the Murine Submandibular Gland
Published on: May 3, 2018
Novel technique to control hypersecretion from a transplanted autologous submandibular salivary gland for
Igal Leibovitch1, Erika Hoyama, Vanessa Limawararut
1Oculoplastic and Orbital Unit, Department of Ophthalmology and Visual Sciences, University of Adelaide, South Australia, Australia. leiboigal5@yahoo.com.au
Purpose:
To present a novel technique to control hypersecretion from a transplanted autologous submandibular gland (SMG) in a patient with keratoconjunctivitis sicca.
Methods:
A 65-year-old man presented with corneal epithelial edema and suspicious ocular surface dysplasia secondary to hypersecretion from a transplanted autologous SMG. The location and function of the gland were evaluated perioperatively using technetium-99m-pertechnetate scintigraphy. The course of the duct was marked with a radiation probe, surgically exposed, and partially ligated with titanium clips.
Results:
Marked reduction in salivary flow and resolution of corneal edema and ocular surface changes were noted. Conjunctival biopsy showed no evidence of malignancy. Symptoms were stable during a 1-year follow-up period.
Conclusion:
Partial ligation of the transplanted SMG duct may be a simple and reversible technique to control hypersecreting glands with secondary corneal edema and ocular surface changes.
