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The mouse as a model for human biology: a resource guide for complex trait analysis
Luanne L Peters1, Raymond F Robledo, Carol J Bult
1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. luanne.peters@jax.org
Nature Reviews. Genetics
|December 19, 2006
Summary
Mice are crucial for understanding human genetics and disease. This review details valuable mouse resources and offers guidelines for analyzing complex traits using genomics research.
Area of Science:
- Genetics
- Genomics
- Physiology
- Pathophysiology
Background:
- Mice have historically served as a key model organism in biomedical research.
- Extensive mouse resources have been developed for cancer research and transplantation biology.
- Current research focuses on dissecting the genetic basis of complex human diseases using mice.
Purpose of the Study:
- To review the accumulated mouse resource infrastructure.
- To provide practical guidelines for utilizing these resources.
- To focus on the analysis of quantitative traits in genomics research.
Main Methods:
- Review of existing mouse model resources.
- Synthesis of practical guidelines for resource utilization.
- Focus on methodologies for quantitative trait analysis.
Main Results:
- An extensive infrastructure of mouse resources is available for research.
- Guidelines are provided for effective use of these resources.
- Specific recommendations for analyzing quantitative traits are highlighted.
Conclusions:
- Mouse resources are indispensable for advancing human physiology and pathophysiology research.
- Effective utilization of these resources, guided by practical insights, is key for genomics studies.
- The review facilitates the application of mouse models in complex disease and quantitative trait analysis.
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