The mouse as a model for human biology: a resource guide for complex trait analysis
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Updated: Jul 18, 2026
A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
Luanne L Peters1, Raymond F Robledo, Carol J Bult
1The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. luanne.peters@jax.org
Abstract:
The mouse has been a powerful force in elucidating the genetic basis of human physiology and pathophysiology. From its beginnings as the model organism for cancer research and transplantation biology to the present, when dissection of the genetic basis of complex disease is at the forefront of genomics research, an enormous and remarkable mouse resource infrastructure has accumulated. This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits.
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