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Osteoporosis in Rett syndrome: A study on normal values
Lilit Zysman1, Meir Lotan, Bruria Ben-Zeev
1National Evaluation Team, Israel Rett Syndrome Center and Chaim Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel.
Thescientificworldjournal
|December 19, 2006
Summary
Osteoporosis in Rett syndrome (RS) is linked to lower bone strength. Increased calcium intake positively impacts bone density and strength in individuals with RS, reducing fracture risk.
Area of Science:
- Orthopedics
- Pediatrics
- Genetics
Background:
- Osteoporosis, characterized by reduced bone density, typically affects postmenopausal women but can occur in younger individuals with chronic conditions.
- Rett syndrome (RS) is associated with early-onset osteoporosis, leading to fractures, pain, and mobility issues, significantly impacting quality of life.
Purpose of the Study:
- To review current knowledge on osteoporosis in Rett syndrome.
- To suggest clinical management strategies for osteoporosis in RS patients.
- To present new findings on bone strength screening in individuals with RS.
Main Methods:
- A screening test of bone strength was conducted on 35 individuals with Rett syndrome using the Sunlight Omnisense 7000P ultrasound apparatus.
- Statistical analysis was performed to identify correlations between calcium intake, bone strength, bone density Z values, and fracture occurrence.
Main Results:
- A significant positive correlation was observed between calcium intake and bone strength (p < 0.0001) and bone density Z values (p < 0.005).
- Reduced bone strength in the radius (p < 0.0001) and tibia (p < 0.004), and negative bone strength Z values (p = 0.03) were associated with increased fracture occurrence and frequency.
Conclusions:
- Findings support a strong link between calcium intake and improved bone health in individuals with Rett syndrome.
- Implementing comprehensive anti-osteoporotic preventive management is recommended for this population to mitigate fracture risk and improve bone health.
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