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Modeling zinc enzyme inhibition with functional thiolate ligands

Teame Tekeste1, Heinrich Vahrenkamp

  • 1Institut für Anorganische und Analytische Chemie der Universität Freiburg, Albertstrasse 21, D-79104 Freiburg, Germany.

Inorganic Chemistry
|December 19, 2006
PubMed
Summary

Researchers modeled zinc enzyme inhibition using functional thiols. Hydrogen bonding significantly influences inhibitor attachment, affecting reaction rates in zinc-thiolate complexes.

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