[Model of eradication of tuberculosis in children in an area with high epidemiological potential]

Revista De Igiena, Bacteriologie, Virusologie, Parazitologie, Epidemiologie, Pneumoftiziologie. Pneumoftiziologia
|April 1, 1975
PubMed

Insights

A 1972 tuberculosis prevention program in children using tuberculin testing and BCG vaccination significantly reduced new cases and eliminated severe forms of the disease. This initiative demonstrated a substantial decrease in tuberculosis incidence and mortality among children.

Area of Science:

  • Public Health
  • Pediatric Medicine
  • Epidemiology

Context:

  • Tuberculosis (TB) remains a significant global health challenge, particularly in pediatric populations.
  • Early detection and prevention strategies are crucial for controlling TB transmission and reducing disease burden.
  • The Drajna dispensary in Prahova County implemented a comprehensive TB control initiative in 1972.

Purpose:

  • To evaluate the effectiveness of a combined approach of tuberculin testing and BCG vaccination in preventing and eliminating childhood tuberculosis.
  • To assess the impact of mass screening and vaccination campaigns on TB incidence and severity in children.
  • To determine the feasibility of scaling up successful interventions county-wide.

Summary:

  • Over 31,000 children aged 1-14 were screened using PPD-IC65 tuberculin, with 12.6% showing positive reactions.
  • 22,779 children were vaccinated with the BCG (Pasteur-Paris strain).
  • Radiological screening of reactors identified 24 new asymptomatic TB cases, indicating an efficiency of 0.8/1000 children tested.

Impact:

  • The intervention led to a 5-fold reduction in TB indicators by 1973, with severe forms and deaths disappearing.
  • BCG-vaccinated children showed a reduced annual risk of developing TB (4.4/100,000).
  • Extending these measures county-wide is projected to rapidly improve pediatric TB epidemiometric indicators.

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.