[Follicular keratosis and multiple myeloma]

Area of Science:

• Dermatology
• Oncology
• Internal Medicine

Background:

• Follicular keratosis is a rare paraneoplastic condition with unclear causes.
• It is occasionally associated with multiple myeloma, with parallel diagnostic and clinical courses.

Observation:

• A 57-year-old female patient with a history of multiple myeloma for 8 years presented with a new skin condition.
• She developed widespread follicular hyperkeratotic spicules.

Findings:

• The onset of generalized follicular hyperkeratotic spicules coincided with the leukemic transformation of her multiple myeloma.
• This suggests a potential paraneoplastic relationship between the skin findings and myeloma progression.

Implications:

• This case underscores the importance of recognizing follicular keratosis as a potential paraneoplastic manifestation in multiple myeloma patients.
• Further research into the etiopathogeny of follicular keratosis in the context of hematologic malignancies is warranted.