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[SAPHO syndrome].

A C Rebollo Aguirre1, D Cabello García, M D Sánchez González

  • 1Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, España. angelc.rebollo.sspa@juntadeandalucia.es

Revista Espanola De Medicina Nuclear
|December 19, 2006
PubMed
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SAPHO syndrome, a rare condition causing sternal and joint pain, was diagnosed in two young men. Bone scintigraphy aided in diagnosis and monitoring treatment response for these osteoarticular diseases.

Area of Science:

  • Rheumatology
  • Nuclear Medicine
  • Orthopedics

Background:

  • SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) syndrome is a rare autoinflammatory disorder.
  • It primarily affects the anterior chest wall, including the sternum and sternoclavicular joints.
  • Diagnosis can be challenging due to its rarity and varied presentation.

Observation:

  • Two male patients, aged 23 and 27, presented with chronic sternal and sternoclavicular joint pain.
  • Initial laboratory tests were within normal limits.
  • Clinical, radiological, and scintigraphic findings were crucial for diagnosis.

Findings:

  • SAPHO syndrome was diagnosed based on a comprehensive evaluation of clinical, radiological, and scintigraphic data.
  • Bone scintigraphy proved valuable for whole-body imaging and differential diagnosis.

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  • Scintigraphy also facilitated monitoring disease progression and therapeutic effectiveness.

    • Implications:

    • This case report highlights the utility of bone scintigraphy in diagnosing SAPHO syndrome.
    • Early and accurate diagnosis is essential for effective management of SAPHO syndrome.
    • Bone scintigraphy serves as a key tool for differential diagnosis of osteoarticular conditions.