Related Experiment Video
Updated: Jul 18, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Preparation of multifunctional glyconanoparticles as a platform for potential carbohydrate-based anticancer vaccines
Rafael Ojeda1, Jose Luis de Paz, Africa G Barrientos
1Grupo de Carbohidratos, Laboratory of Glyconanotechnology, Instituto de Investigaciones Químicas-CSIC, Américo Vespucio, 49, E-41092 Seville, Spain.
Abstract:
A novel platform for anticancer vaccines has been prepared using glyconanotechnology recently developed in our laboratory. Ten different multifunctional gold glyconanoparticles incorporating sialylTn and Lewis(y) antigens, T-cell helper peptides (TT) and glucose in well defined average proportions and with differing density have been synthesised in one step and characterised using NMR and TEM. Size and nature of the linker were crucial to control kinetics of S-Au bond formation and to achieve the desired ligand ratio on the gold clusters. The technology presented here opens the way for tailoring polyvalent anticancer vaccines candidates and drug delivery carriers with defined average chemical composition.
More Related Videos
Related Concept Videos
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Tumor Immunotherapy
Glycocalyx and its Functions
Components of...

