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Updated: Jul 18, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of
Enrique Baca-Garcia1, Concepcion Vaquero-Lorenzo, Montserrat Diaz-Hernandez
1Department of Psychiatry, Fundacion Jimenez Diaz Hospital, Avenida Reyes Catolicos 2, 28040, Madrid, Spain. ebacgar2@yahoo.es
Background:
Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD.
Methods:
The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians.
Results:
Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls.
Conclusions:
Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
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